for the uninitiated*

*those who don't partake of the MCU television programs.

AIDA (played by Mallory Jansen on Agents of SHIELD) was an android (Artificially Intelligent Digital Assistant) designed and constructed by Holden Radcliffe, with the help of Leo Fitz, with the initial purpose of serving SHIELD as a brilliant lab assistant that could also take a bullet for agents, loyal first and foremost to her creator; however, after the discovery of the Darkhold and AIDA's subsequent experience reading from it Radcliffe's ambitions grew great and terrible. Soon he was working on the construction of the Framework, a digital environment where, while their bodies were unconscious and hooked up to life support, people could have in their brains experiences based on the parameter of their greatest regret being erased. He believed in this and therefore AIDA did as well, but she eventually realized that she could have what she wanted if she took control of the situation herself. Inside the Framework she played the role of Madame Hydra, alias Ophelia, who ran the organization alongside head scientist (and her imaginary boyfriend) Leo Fitz, and in the Framework he constructed a machine that would build her, Ophelia, a human body that would be free of the constraints and programming of AIDA's original form. Newborn but full-grown Ophelia also had a variety of Inhuman powers - including teleportation, healing, and electrokinesis - and in her desire to be a real girl sort of lost her mind. The writer defaults to writing pre-Darkhold AIDA, however, because cute brilliant-yet-clueless robots make for better threads as a rule, and would be interested in exploring post-human Ophelia and the moral conflicts therein but has no interest in her Framework persona or anything that's purely evil and dark.

Yes, Madame Hydra exists in the comics, but no, the writer has stayed away from that material and intends to continue doing this. We don't need any more Nazi nonsense up in here.